利用远红外陶瓷微珠作为干预手段,对大鼠肌肉急性损伤后进行恢复治疗,探讨其对骨骼肌血清炎症指标LZM、MPO和免疫学IL-10、IL-8指标的影响.将88只SD雄性大鼠分为A组安静对照组;B组模型组;C组模型+热水组;D组模型+陶瓷微珠组,大鼠急性损伤造模成功后自然休息48 h后,各组实验大鼠按照设计分别取干预后第3 d、4 d、6 d、7 d时相点数据进行组内、组间分析.结果:①干预后第3 d,D组血LZM、IL-10恢复后各时相水平均显著高于自然恢复B组与模型C组(P<0.05);②干预后7 d,D组血MPO、IL-8恢复水平均显著低于自然恢复B组与模型C组(P<0.01).结论:①远红外陶瓷微珠干预下,发现降低了MPO水平而提升了LZM水平,说明干预后急性损伤炎性细胞对损伤肌肉的破坏进一步减小;②远红外陶瓷微珠干预可提升IL-10浓度水平和降低IL-8的浓度水平,验证其影响炎症反应过程,促进急性损伤的快速恢复.
Abstract
The paper investigates serum inflammatory markers indicators MPO, LZM and immunological of IL-10, IL-8 after far-infrared ceramic as a means of intervention in rats with acute injury treatment to restore skeletal muscle. 88 male SD rats were divided into four groups: Group A, control group; Group B model group; Group C, models+hot water group; Group D models + ceramic set of model group. After acute injury and natural resting 48 h later, the data of each group were taken at 3,4,6,7 d phase point analyses were done within the group, between-group in accordance. Results: 1)3 day after the intervention , D group blood LZM, IL-10 recovery after each phase were significantly higher than the natural recovery group B with the model group C (P<0.05); 2) Group D blood MPO, IL-8 levels restored very significantly, lower than the natural recovery group B and C group (P<0.01) after 7 days intervention. Conclusions: 1) Ceramic intervention can reduce further damage to the inflammatory cells after acute muscle injury to by increasing the levels of MPO,LZM levels; 2) the far-infrared ceramic microspheres can promote the recovery of acute injury can enhance IL-10, and reduce IL-8 levels.
关键词
远红外陶瓷微珠 /
白介素-10 /
溶菌酶 /
急性损伤 /
血清髓过氧化物酶
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Key words
far-infrared ceramic microspheres(FICM) /
interleukin-10 /
lysozyme /
acute injury /
serum myeloperoxidase
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脚注
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基金
福建省自然科学基金资助项目(2016J01404);莆田学院育苗基金资助项目(2017014);莆田学院国家基金预研资助项目(2016076);国家体育总局科技服务资助项目(2017HT008)
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