Since the 18th CPC National Congress, Hangzhou has made breakthrough achievements in innovating local anti-corruption culture, embodied in the four modes, namely, individualization, internalization, dataization and resourceization. However, at present, the construction of a clean and honest administration in Hangzhou still faces such real predicaments as lack of innovation capacity, low participation and lack of effective coordination. The issues in Hangzhou′s anti-corruption culture is the combining result of the hysteresis of relevant system design within the region, the influential local business culture and the insufficient participation of regional social organizations. As an example of the developed regions, the practice of building a clean and honest administration in Hangzhou is of expansive and enlightening value. It suggests that to promote the construction of an anti-corruption culture in our country in the new era, it is necessary to strengthen the concept innovation, consolidate the guiding core, perfect the relevant mechanisms and social foundation, and promote the performance evaluation.