The commercial space under the influence of information technology is an important issue, and the new retail with deep integration of “ online + offline + logistics” has developed rapidly in re- cent years. Exploring commercial space location characteristics from a micro-level is conducive to optimizing its location layout. This paper is based on multi-source data and uses ArcGIS spatial analysis, quantitative statistical analysis, and field research methods to analyze the spatial pattern and micro-lo- cation characteristics of Freshippo stores in Guangzhou. The main conclusions are that: ① Freshippo stores in Guangzhou are mainly distributed in the central urban area, having a dispersed characteristic; ② Micro-location selection tends to be in areas with high road density, convenient public transportation, high population density, high income level, and a predominantly young and middle-aged group; ③ Freshippo stores in Guangzhou present a complementary relationship with traditional physical commerce, relying on mid to high level commercial districts and commercial squares for location selection, relatively close to traditional large supermarkets, but far from new retail supermarkets of the same type; ④ The business model of new retail weakens the orientation of optimal location selection. Freshippo stores in Guangzhou are located in mid to high level commercial districts with a moderate land price, and their stores layout are mainly based on an interior model. Most stores are not located on the best ground floor.