Based on the thermodynamic method, NRTLRK, Aspen plus software was used to simulate isopropyl alcohol production process by transesterification and optimized design of energy saving, which is catalyzed by sodium methanol solid catalyst. The project used 50 000 tons isopropyl alcohol production per year, while the factors of reaction equilibrium, separation difficulty and cost of raw materials are considered for reactor design. The reactive distillation column is set as isopropyl alcohol synthesis reactor. The bottoms flow is 99.99 wt% of isopropyl alcohol. The pressure swing distillation system design is based on the thermal characteristics of flow from the top of the reactive distillation column, which can achieve the goals of recycle the byproducts, methyl acetate, and the raw material, methanol. Heat pump distillation and double effect distillation technologies are adopted in reactive distillation and pressure swing distillation systems, respectively. While the energy consumption values decrease 60.2% and 43.9% respectively, the heat exchange network energy was further integrated, and the final energy consumption was reduced by 59.2% .